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Why some get sicker than others, does this apply to COVID_19? 'Children with recurrent Strep infections had smaller immune structures crucial to the development of antibodies in the Tonsils than kids who hadn't had repeated infections, researchers found.' https://www.sciencenewsdigital.org/sciencenews/march_2__2019/MobilePagedArticle.action?articleId=1465181
"Team looked at sections of tissue under microscope & found that kids with recurring strep had smaller immune structures called germinal centers, and the centers had fewer of a particular kind of immune cell, a type of T cell." Para 5, Body & Brain Sci News, 3/2/19
Coronavirus research: 'For reasons that aren’t entirely clear, some people—especially the elderly and sick—may have dysfunctional immune systems that fail to keep the response to particular pathogens in check.' https://www.the-scientist.com/news-opinion/why-some-covid-19-cases-are-worse-than-others-67160
Cont. "This could cause an uncontrolled immune response, triggering an overproduction of immune cells and their signaling molecules and leading to a cytokine storm often associated with a flood of immune cells into the lung."
Local inflammation can turn into widespread inflammation of the lungs, which then has ripple effects across all organs of the body. This could also happen if the virus replicates faster than the immune system can respond.. cont. from http://the-scientist.com link above
.."so that it then has to play catch-up to contain the pathogen—a situation that could also cause the immune defense to spiral out of control.--Genetic and environmental risk factors might help explain the severity of infections." https://www.the-scientist.com/news-opinion/why-some-covid-19-cases-are-worse-than-others-67160
