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“Doc, I don’t trust the Covid-19 vaccine because it’s too rushed. Normally, vaccines take 7-10 years.”Here is a thread to reassure you that the Covid-19 vaccine is as safe as possible, with only one year of effective & accelerated research.
1/15
Firstly, 7-10 years is not automatically safe. Most of it is spent waiting, not researching.
Scientists wait for money, for approvals by committees who meet twice a year, or for paperwork.
They also wait for patients to join their trials; this is a major wait.
2/15
Scientists wait for money, for approvals by committees who meet twice a year, or for paperwork.
They also wait for patients to join their trials; this is a major wait.
2/15
Many things can change in those 7-10 years.
Scientists move to new jobs or they lose interest. Drug companies change leaders, who then change research agendas or marketing strategies.
You see, science has real-life problems like other companies too.
3/15
Scientists move to new jobs or they lose interest. Drug companies change leaders, who then change research agendas or marketing strategies.
You see, science has real-life problems like other companies too.
3/15
Secondly, vaccine research can take 7-10 years because money is limited.
Money is limited because most infectious diseases are in tropical countries. But pharma is largely in US, Europe or Japan. Pharma doesn’t invest in tropical diseases because it’s not profitable.
4/15
Money is limited because most infectious diseases are in tropical countries. But pharma is largely in US, Europe or Japan. Pharma doesn’t invest in tropical diseases because it’s not profitable.
4/15
It’s true that TB, malaria & dengue are serious.
But it’s also true that they don’t have the global scale, severity & urgency of Covid-19. So, pharma invests a lot more for a Covid vaccine because it’s likely more profitable.
More money = faster research.
5/15
But it’s also true that they don’t have the global scale, severity & urgency of Covid-19. So, pharma invests a lot more for a Covid vaccine because it’s likely more profitable.
More money = faster research.
5/15
Thirdly, governments and philanthropies also gave a lot of money into Covid vaccine research.
This was much higher compared to the history of vaccine research. It’s also much higher than other branches of science in 2020.
More money = faster research.
6/15
This was much higher compared to the history of vaccine research. It’s also much higher than other branches of science in 2020.
More money = faster research.
6/15
Fourthly, science is so much more advanced in 2020 compared to history.
That helped accelerate Covid-19 vaccine research. Other vaccines needed 7-10 years because they were using less advanced technology.
7/15
That helped accelerate Covid-19 vaccine research. Other vaccines needed 7-10 years because they were using less advanced technology.
7/15
Fifthly, the world has more vaccine scientists in 2020 compared to history.
They were supported by more biologists, chemists, immunologists, manufacturing experts etc, compared to history.
EVERYONE worked together to compress 7-10 years of work into one year.
8/15
They were supported by more biologists, chemists, immunologists, manufacturing experts etc, compared to history.
EVERYONE worked together to compress 7-10 years of work into one year.
8/15
Six, vaccine scientists were building on previous work on mRNA and coronaviruses.
They didn’t start from zero.
Previous research and knowledge allowed them to accelerate their research into the Covid-19 vaccine.
9/15
They didn’t start from zero.
Previous research and knowledge allowed them to accelerate their research into the Covid-19 vaccine.
9/15
Seven, scientists had many volunteers for the Covid vaccine.
Pfizer recruited 40K subjects, Moderna 30K, AZ/Oxford 20K.
These are very large numbers usually achieved over 2-5 years. But it was much easier to find volunteers for Covid-19.
10/15
Pfizer recruited 40K subjects, Moderna 30K, AZ/Oxford 20K.
These are very large numbers usually achieved over 2-5 years. But it was much easier to find volunteers for Covid-19.
10/15
Eight, pharma was backed by market guarantees.
This is when governments basically promised to buy the vaccines if they were successful, BEFORE the research even started.
This gave scientists an incentive to work faster & harder, and pharma to invest more money.
11/15
This is when governments basically promised to buy the vaccines if they were successful, BEFORE the research even started.
This gave scientists an incentive to work faster & harder, and pharma to invest more money.
11/15
Nine, Covid saw much greater collaboration (by data sharing) & competition (>100 vaccine candidates) than other infectious diseases.
Other infectious diseases maybe had 1-2 companies competing over 10 years, with little data-sharing.
Collab + Compete = faster research.
12/15
Other infectious diseases maybe had 1-2 companies competing over 10 years, with little data-sharing.
Collab + Compete = faster research.
12/15
Ten, there’s no "single magic reason" why the Covid vaccine was successful after one year.
Many reasons combined for this triumph of science. Ten years of inefficient work was compressed into one super-effective year.
13/15
Many reasons combined for this triumph of science. Ten years of inefficient work was compressed into one super-effective year.
13/15
Of course, more long-term data is always helpful.
But the “endless chase for perfect data” requires a separate thread.
This thread is to explain how research was conducted in one year for a safe & effective vaccine. Meanwhile, Covid-19 rages around us.
14/15
But the “endless chase for perfect data” requires a separate thread.
This thread is to explain how research was conducted in one year for a safe & effective vaccine. Meanwhile, Covid-19 rages around us.
14/15
This vaccine is a triumph of science.
After NPRA approvals, we should be confident in its safety.
Although only a year, it was Very Well Spent.
It proves that clever scientists can achieve wonders, if given enough money & political will.
I will take it happily.
15/15
After NPRA approvals, we should be confident in its safety. Although only a year, it was Very Well Spent. It proves that clever scientists can achieve wonders, if given enough money & political will. I will take it happily.15/15
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