#TMPRSS2

Julien Potet

julienpotet

1/ Short thread on #TMPRSS2, a cellular protease that plays a critical role for SARS-CoV-2 entry into host cells. #COVID19 Disclaimer: I have limited expertise in microbiology. If you notice

Matt Hall

cispt2

We've posted an updated version of @ScientistShrimp @sckales TMPRSS2 @biorxivpreprint with some new information about active enzyme concentration in the assay. We also show the camostat metabolite is almost as

Wezi Sendama

wezisendama

I've got a new paper about using the computer to find drugs that might stop coronavirus entering cells in the lab. I should stress that that's very, *very* far removed

Kobayashi Maru

knowing_what_is

Niclosamide(Auf deutsch: Niclosamid)(deutscher Handelsname: Yomesan)(It MIGHT help with prophylaxis and/ or treatment of Covid-19 and might lessen the severity of the disease, but remember: this is not medical advice!, check

Mark F. McCarty

markfmccarty

@Covid19Crusher @jpkiekens @Ian56789 @gummibear737 How to Crush COVID-19 with Early Treatment SARS-CoV-2 gets into cells either via endosomes, or directly thru the plasma membrane. This requires fusion of the viral

Dr. Angela Rasmussen

angie_rasmussen

This is a great piece from @rkhamsi about a topic that people often don't think about: it's REALLY important to consider the types of cells being used for in vitro

Eugene Ong

uginong

Summary of ‘Naturally mutated spike proteins of SARS-CoV-2 variants show 2 differential levels of cell entry’ preprint by Ozono et al., 2020. https://doi.org/10.1101/2020.06.15.151779Disclaimer: This summary is shared as a first-time

Anand Ranganathan

ARanganathan72

Demographic breakdown by Age for India and Italy, and Death Rate by Age for #COVID19. #CoVID19Global Case Fatality Rate (CFR): 3.5%[(3800 deaths / 110,000 confirmed cases) X 100]1. CFR will

robert rosencrans

rfrosencrans

In #RaceInABottle, Jonathan Kahn exhaustively documented these studies. Tiny, non-random samples extrapolated to millions. Bad statistics + bad theory. I prefer a different subgroup, repeatedly shown to have biologic import:

Mohammad Ansarin

mansarin

Finally a drug that seems to work well against COVID-19: Tabriz Uni of Med Sci team find Bromhexine prevents all treated patients in randomized trial from dying, almost all from

The Menachery Lab

TheMenacheryLab

Our study examining a furin-cleavage site deletion mutant in #COVID19 is now out @Nature With a short thread (cause who has time to read beyond twitter) (1/6https://go.nature.com/2MnGlfq First, thanks to

Roxana Daneshjou MD/PhD

RoxanaDaneshjou

I would like to lay out why this work is scientifically unsound and problematic. Note that my PhD was in a genetics/informatics lab, and I spent time working with population

Rüdiger Groß

r_gross_

Clinical studies have found impaired glucose homeostasis & ketoacidosis in COVID-19 patients - begs the question: does COVID-19/SARS-CoV-2 cause diabetes? We get closer to finding an answer with our new

Jason Pogue

jpogue1

I promise that if #hydroxychloroquine was an effective therapy for #covid19 we would tell you. Many of us (myself definitely included) were hopeful that it would be at the onset

Walter M Chesnut

Parsifaler

1) RETWEET!!!!!! THE SPIKE PROTEIN OF SARS-CoV-2 IS A "SUPERALLERGEN"!!!!!!! WE ARE "ALLERGIC" TO IT!!!The curious case of MIS-C brings an important concept to mind. Children that present with MIS-C,

Imran S. Haque

ImranSHaque

Happy Monday! In today's #tweetorial on our recent preprint describing @RecursionPharma's platform (https://www.biorxiv.org/content/10.1101/2020.08.02.233064v1), I'll explain the unusual 2-D drug response plots we use there and

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